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This article is part of the supplement: AIDS Vaccine 2009

Open Access Oral presentation

OA011-01. Early events of human immunodeficiency virus type 1 (HIV-1) ex vivo penetration in the foreskin mimicking HIV-1 sexual transmission

Y Ganor1*, Z Zhou1, A Schmitt1, M Vacher-Lavenu2, L Gibault2, N Thiounn3, J Tomasini4, J Wolf5 and M Bomsel1

  • * Corresponding author: Y Ganor

Author Affiliations

1 Cellular Biology and Host-Pathogen Interactions, Cochin Institute, Paris, France

2 Anatomy & Pathological Cytology Service, GH Cochin-St Vincent de Paul, Paris, France

3 Urology Service, Necker Hospital, Paris, France

4 Geoffroy St Hillaire Clinic, Paris, France

5 Reproductive Biology Service, GH Cochin-St Vincent de Paul, Paris, France

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Retrovirology 2009, 6(Suppl 3):O7 doi:10.1186/1742-4690-6-S3-O7

Published: 22 October 2009

First paragraph (this article has no abstract)

Although male circumcision was reported to reduce male acquisition of HIV-1 by 60%, the initial mechanisms of HIV-1 transmission at the male genitals remain elusive. A chief problem in studying the early phases of foreskin HIV-1 infection is the lack of proper in vitro model systems that reflect the in vivo architecture.