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This article is part of the supplement: AIDS Vaccine 2009

Open Access Oral presentation

OA011-02. Defining the mechanisms of HIV entry and interactions with the female genital tract

AM Carias1*, S McCoombe1, M McRaven1, M Anderson1, R Veazey2 and TJ Hope1

  • * Corresponding author: AM Carias

Author Affiliations

1 Cell and Molecular Biology, Northwestern University, Chicago, IL, USA

2 Tulane National Primate Center, Covington, LA, USA

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Retrovirology 2009, 6(Suppl 3):O8 doi:10.1186/1742-4690-6-S3-O8

Published: 22 October 2009

First paragraph (this article has no abstract)

To date, little is known about the mechanisms of the sexual transmission of HIV and how the virus interacts with the female genital epithelium to gain access to underlying target cells. We illustrate that HIV is able to penetrate both intact columnar and squamous epithelium in explants and the living rhesus macaque. Through a series of approaches we were able to determine the mechanism of HIV entry into these tissues.