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This article is part of the supplement: AIDS Vaccine 2009

Open Access Oral presentation

OA011-03. Clusterin, a natural ligand of DC-SIGN present in human semen inhibits HIV capture and transmission by dendritic cells

J Sabatte3,1,2*, W Faigle7, A Ceballos1, W Morelle4, C Rodríguez1, F R Lenicov1, M Thépaut4, F Fieschi4, H Lortat-Jacob4, J Michalski5, F Arenzana-Seisdedos6, J Geffner1 and S Amigorena7

  • * Corresponding author: J Sabatte

Author Affiliations

1 National Reference center for AIDS, Buenos Aires, Argentina

2 Institut Curie, Paris, France

3 Institut de Biologie Structurale, UMR CNRS-CEA-UJF, Grenoble, France

4 Institut de Biologie Structurale, UMR CNRS-CEA-UJF, Grenoble, France

5 UMR CNRS 8576, Unité de Glycobiologie Structurale et fonctionnelle, Lille, France

6 Unité d'Immunologie Virale, Institut Pasteur, Paris, France

7 U932 INSERM, Institut Curie, Immunité et Cancer, Paris, France

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Retrovirology 2009, 6(Suppl 3):O9 doi:10.1186/1742-4690-6-S3-O9

Published: 22 October 2009

First paragraph (this article has no abstract)

Although sexual transmission represents the main mode of HIV dissemination worldwide, little is known about the influence of semen on viral spread. We have shown that seminal plasma (SP) inhibits both, the attachment of HIV to dendritic cells (DC) and the ability of DC to transmit the virus to T cells. Here, we characterized the inhibitor present in SP and their functional properties.