Absence of xenotropic murine leukaemia virus-related virus in UK patients with chronic fatigue syndrome
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* Corresponding author: Kate N Bishop kbishop@nimr.mrc.ac.uk
Retrovirology 2010, 7:10 doi:10.1186/1742-4690-7-10
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BioMed Central: 7 citations
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Editorial
Equal versus equivalent access to the scientific literature Kuan-Teh Jeang Retrovirology 2011, 8:83 (21 October 2011) The concepts of equal versus equivalent access to the scientific literature are discussed.
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Research
Mir A Ali, Janet K Dale, Christine A Kozak, Raphaela Goldbach-Mansky, Frederick W Miller, Stephen E Straus, Jeffrey I Cohen Virology Journal 2011, 8:450 (24 September 2011) |
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Review
Jonathan P Stoye, Robert H Silverman, Charles A Boucher, Stuart FJ Le Grice Retrovirology 2010, 7:113 (22 December 2010) The 1st International Workshop on Xenotropic Murine Leukemia Virus-Related Retrovirus (XMRV) was convened on September 7/8 on the NIH campus, Bethesda, MD. The current status of XMRV research, concerns among the scientific community and suggestions for future actions are summarized in this meeting report.
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Research
Mouse DNA contamination in human tissue tested for XMRV Mark J Robinson, Otto W Erlwein, Steve Kaye, Jonathan Weber, Oya Cingoz, Anup Patel, Marjorie M Walker, Wun-Jae Kim, Mongkol Uiprasertkul, John M Coffin, Myra O McClure Retrovirology 2010, 7:108 (20 December 2010) These results show that contamination with mouse DNA is widespread and detectable by the highly sensitive IAP assay, but not always with less sensitive assays, such as murine mtDNA PCR. This study highlights the ubiquitous presence of mouse DNA in laboratory specimens and offers a means of rigorous validation for future studies of murine retroviruses in human disease.
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Opinion
A cautionary tale of virus and disease Robin A Weiss BMC Biology 2010, 8:124 (27 September 2010) Retroviral origins have been correctly assigned to AIDS and a rare T cell leukemia, but doubtfully assigned to many more diseases. Robin Weiss explains the chequered history of so-called RNA rumor viruses in the light of recent conflicting reports on chronic fatigue syndrome.
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Research
Xiaoxing Qiu, Priscilla Swanson, Ka-Cheung Luk, Bailin Tu, Francois Villinger, Jaydip Das Gupta, Robert H Silverman, Eric A Klein, Sushil Devare, Gerald Schochetman, John Hackett Retrovirology 2010, 7:68 (17 August 2010) Three rhesus macaques were infected with XMRV to determine the dynamics of the antibody responses elicited by infection with XMRV. All macaques developed antibodies to XMRV during the second week of infection, and the predominant responses were to the envelope protein gp70, transmembrane protein p15E and capsid protein p30. In general, antibody responses to gp70 and p15E appeared early with higher titers than to p30, especially in the early period of seroconversion. Antibodies to gp70, p15E and p30 persisted to 158 days and were substantially boosted by re-infection, thus, were identified as useful serologic markers.
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Research
William M Switzer, Hongwei Jia, Oliver Hohn, HaoQiang Zheng, Shaohua Tang, Anupama Shankar, Norbert Bannert, Graham Simmons, R Michael Hendry, Virginia R Falkenberg, William C Reeves, Walid Heneine Retrovirology 2010, 7:57 (1 July 2010) Recent reports suggesting xenotropic murine leukemia virus (XMRV) as the etiological agent in chronic fatigue syndrome (CFS) contradicted by molecular and serological assay of US population archives.
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