Table 2

Neutralisation properties of different monoclonal antibodies against XMRV and MLV pseudotyped with three different envelopes.

Neutralisation of

Hybridoma1

Raised in

Isotype

XMRV

MLV(X)

Friend

Moloney


83A25'

Rat

IgG2A

Y (88)

Y (89)

ND

ND

24-7

Mouse

IgMK

N

N

ND

ND

48

Mouse

IgG2A

N

N

Y (95)

Y (83)

538

Mouse

IgM

N

N

N

Y (63)

603

Mouse

IgM

N

Y (96)

N

ND

609

Mouse

IgM

Y (71)

N

ND

ND

610

Mouse

IgM

N

Y (64)

ND

ND

613

Mouse

IgM

N

Y (91)

ND

ND

615

Mouse

IgM

N

N

ND

ND


Y indicates neutralisation; N indicates no neutralisation; ND is not determined

The number in brackets refers to the percentage neutralisation at the least diluted antibody concentration.

1 See references [13] and [14] for description of hybridoma cell lines

Groom et al. Retrovirology 2010 7:10   doi:10.1186/1742-4690-7-10

Open Data