Figure 5.

HIV-1 sensitivity to sCD4-40-17b: independence from cellular source of virions. IMCs from strains BL01 and 89.6 were used to generate virus particles directly from transfected 293T cells; a second set of viruses was generated by single passage of the 293T-derived particles in PBMCs [30]. Both sets of particles (directly provided to us by M. Louder and J. Mascola) were analyzed for sensitivity to the agents shown. The results are plotted as the IC₅₀ ratios of the PBMC-passaged to the 293T-derived virus particles. In each graph, the dotted line indicates a ratio of 1 (i.e., equal potency against each type of virus particle).