Commentary
Journey to the heart of macrophages: the delicate relationship between HIV-1 and a multifaceted cell type
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Correspondence: Andrea Cimarelli acimarel@ens-lyon.fr
LaboRetro, Department of Human Virology, Ecole Normale Supérieure de Lyon, Lyon, France
INSERM, U758, Lyon, France
University of Lyon 1, IFR128 BioSciences Lyon-Gerland, Lyon-Biopole, Lyon, France
Retrovirology 2010, 7:28 doi:10.1186/1742-4690-7-28
Published: 7 April 2010Abstract
Cells of the monocyte-macrophage lineage play multiple roles during the infection of primate lentiviruses serving as reservoirs for viral production or as vectors for viral spread to other cells and tissues. The human immunodeficiency type I virus is not only capable of establishing such complex and dynamic relations with this cell type, but is also able to modulate their physiology and behavior, thus shaping ensuing cellular immune responses. In this issue of Retrovirology, a series of reviews explores the multiple manners in which the virus and cells belonging to the monocyte-macrophage lineage interact and affect each other.