Table 1 |
||
|
Restrictions that limit HIV-1 replication in monocytes and macrophages. |
||
|
Monocytes |
||
|
|
||
|
Restriction mechanism |
Replication step affected |
Ref. |
|
|
||
|
APOBEC3G APOBEC3A |
Reverse transcription |
[40] |
|
Vpx counteracted factor |
Post-entry Reverse transcription |
[53] |
|
miRNA-198 |
Transcription (down-modulation of CycT1) |
[59] |
|
miRNAs |
Viral mRNA |
[62] |
|
|
||
|
Macrophages |
||
|
|
||
|
Restriction mechanism |
Replication step affected |
Ref. |
|
|
||
|
CCR5 down-regulation, Δ CCR5 |
Entry |
|
|
p21 |
Reverse transcription Integration |
|
|
16 kDa C/EBPβ |
Transcription |
|
|
CTIP2 |
Transcription |
[159] |
|
TRIM22 |
Transcription? Budding and release? |
|
|
PPAR |
Post-integration (?) |
|
|
uPA |
Post-translation, release? |
|
|
|
||
|
Bergamaschi and Pancino Retrovirology 2010 7:31 doi:10.1186/1742-4690-7-31 |
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