Table 3

Inhibition of HIV-1 replication

shRNAs


Target

wt

G8A

G15A

wt+G8A

wt+G8A+G15A


wt

++a (0)b

- (1)

- (1)

++ (0.1)c

++ (0.1.1)c


G8A

- (1)

++ (0)

- (1)

++ (1.0)

++ (1.0.1)


G15A

- (1)

- (1)

++ (0)

- (0.1)

++ (1.1.0)


+G8A+G15A

- (2)

- (1)

++ (1)

- (2.1)

- (2.1.1)


a score of RNAi activity

b number of mismatches

c number of mismatches per shRNA

Schopman et al. Retrovirology 2010 7:52   doi:10.1186/1742-4690-7-52

Open Data