Table 2

Host proteins selectively co-purifying with HIV-1 PICs

Host Proteins

Accession numbers

Molecular Weight

No. of peptides

Chromatin organization

Barrier-to-autointegration factor

baf_bovin

10 kDa

3

Nucleosome assembly protein 1-like 1

np1l1_bovin

45 kDa

5

Histone-binding protein RBBP4

rbbp4_bovin

48 kDa

3

Transcription regulation

Acidic leucine-rich nuclear phosphoprotein 32 family member A

an32a_bovin

29 kDa

4

Acidic leucine-rich nuclear phosphoprotein 32 family member E

an32e_human

31 kDa

3

Calreticulin

calr_cerae

48 kDa

5

NF-kappa-B essential modulator

nemo_bovin

49 kDa

7

Non-POU domain-containing octamer-binding protein

nono_human

54 kDa

8

RNA polymerase-associated protein LEO1

leo1_human

75 kDa

6

RNA processing/localization

ATP-dependent RNA helicase DDX19A

dd19a_bovin

54 kDa

4

Double-stranded RNA-binding protein Staufen homolog 1

stau1_human

63 kDa

2

Heterogeneous nuclear ribonucleoprotein H1

hnrh1_human

49 kDa

2

Heterogeneous nuclear ribonucleoprotein H3

hnrh3_human

37 kDa

3

Plasminogen activator inhibitor 1 RNA-binding protein

pairb_human

45 kDa

7

Splicing factor 3B subunit 2

sf3b2_human

98 kDa

19

Splicing factor, arginine/serine-rich 3

sfrs3_bovin

19 kDa

3

U4/U6.U5 tri-snRNP-associated protein 1

snut1_human

90 kDa

17

Translation

Eukaryotic translation initiation factor 4 gamma 1

if4g1_human

176 kDa

3

Cytoplasmic trafficking

Dynactin subunit 2

dctn2_human

44 kDa

3

The host proteins have been broadly categorized based on the known physiological function. The number of peptides identified by mass spectroscopic analysis and assigned to the specific protein in the database is shown.

Raghavendra et al. Retrovirology 2010 7:66   doi:10.1186/1742-4690-7-66