Table 2 |
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CTL escape at the Gag p11c epitope in breast milk and blood virus quasispecies during acute SIV infection. |
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Weeks after SIV infection |
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|
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|
Animal # |
Week 33 |
Week 35 |
Week 36 |
Week 37 |
Week 38 |
Week 40 |
Week 45 |
|
|
|
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|
206 |
blood |
100%a (14/14)b |
65.4% (17/26) |
59.4% (19/32) |
61.5% (16/26) |
41.7% (10/24) |
30.4% (7/23) |
8.3% (2/24) |
|
milk |
80% (4/5) |
29.0% (9/31) |
83.3% (35/42) |
3.1% (1/32) |
NDc |
ND |
ND |
|
|
|
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|
Week 37 |
Week 39 |
Week 41 |
Week 42 |
Week 45 |
Week 46 |
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|
|
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|
257 |
blood |
100% (16/16) |
ND |
ND |
100% (28/28) |
21.2% (7/33) |
0% (0/17) |
|
|
milk |
ND |
50% (5/10) |
0% (0/5) |
ND |
14.3% (1/7) |
6.7% (1/15) |
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|
|
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|
Week 33 |
Week 35 |
Week 36 |
Week 37 |
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|
|
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|
402 |
blood |
0% (0/22) |
0% (0/35) |
0% (0/27) |
0% (0/19) |
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|
milk |
0% (0/22) |
12.5% (1/8) |
0% (0/15) |
0% (0/5) |
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|
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|
Week 15 |
Week 16 |
Week 17 |
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|
|
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|
403 |
blood |
73.1% (19/26) |
28.0% (7/25) |
0% (0/26) |
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|
milk |
100% (15/15) |
18.5% (5/27) |
4.3% (1/23) |
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|
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a % reported is the proportion of virus quasispecies that did not have an amino acid substitution within the Gag p11C epitope (remained wild type). b In parentheses is the number of virus quasispecies that remained wild type at the Tat TL8 epitope/number of virus quasispecies sequenced. c ND = not done or unable to amplify virus variants |
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|
Permar et al. Retrovirology 2010 7:7 doi:10.1186/1742-4690-7-7 |
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