Characterization of the HIV-1 RNA associated proteome identifies Matrin 3 as a nuclear cofactor of Rev function
-
* Corresponding author: Alessandro Marcello marcello@icgeb.org
Retrovirology 2011, 8:60 doi:10.1186/1742-4690-8-60
Accesses
- Last 30 days: 99 accesses
- Last 365 days: 1822 accesses
- All time: 1822 accesses
Cited by
BioMed Central: 3 citations
|
Oral presentation
Role of cellular factors in the replication of human retroviruses: recent insights Kuan-Teh Jeang Retrovirology 2011, 8(Suppl 2):O21 (3 October 2011) |
|
Commentary
Matrin 3 and HIV Rev Regulation of mRNA Andrew I Dayton Retrovirology 2011, 8:62 (20 July 2011) The nuclear matrix protein, MATR3, is a newly-described Rev cofactor whose mechanism of action is only starting to be revealed.
|
|
Research
Matrin 3 is a co-factor for HIV-1 Rev in regulating post-transcriptional viral gene expression Venkat SRK Yedavalli, Kuan-Teh Jeang Retrovirology 2011, 8:61 (20 July 2011) Previously, Rev co-factors have been found to include cellular factors such as CRM1, DDX3, PIMT and others. In this work, the nuclear matrix protein Matrin 3 is shown to bind Rev/RRE-containing viral RNA. This binding interaction stabilizes unspliced and partially spliced HIV-1 transcripts leading to increased cytoplasmic expression of these viral RNAs.
|