Matrin 3 is a co-factor for HIV-1 Rev in regulating post-transcriptional viral gene expression
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* Corresponding author: Kuan-Teh Jeang kjeang@niaid.nih.gov
Retrovirology 2011, 8:61 doi:10.1186/1742-4690-8-61
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BioMed Central: 3 citations
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Oral presentation
Role of cellular factors in the replication of human retroviruses: recent insights Kuan-Teh Jeang Retrovirology 2011, 8(Suppl 2):O21 (3 October 2011) |
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Commentary
Matrin 3 and HIV Rev Regulation of mRNA Andrew I Dayton Retrovirology 2011, 8:62 (20 July 2011) The nuclear matrix protein, MATR3, is a newly-described Rev cofactor whose mechanism of action is only starting to be revealed.
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Research
Anna Kula, Jessica Guerra, Anna Knezevich, Danijela Kleva, Michael P Myers, Alessandro Marcello Retrovirology 2011, 8:60 (20 July 2011) In this work we exploited a novel proteomic method to identify MATR3 as a cellular cofactor of Rev activity. MATR3 binds viral RNA and is required for the Rev/RRE mediated nuclear export of unspliced HIV-1 RNAs.
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