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Open Access Correction

HIV-1 Vpu and HIV-2 Env counteract BST-2/tetherin by sequestration in a perinuclear compartment

Heiko Hauser1, Lisa A Lopez1, Su J Yang1, Jill E Oldenburg1, Colin M Exline1, John C Guatelli2 and Paula M Cannon1*

Author Affiliations

1 Keck School of Medicine of the University of Southern California, California Los Angeles, CA 90089, USA

2 University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92093, California, USA

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Retrovirology 2011, 8:85 doi:10.1186/1742-4690-8-85


The electronic version of this article is the complete one and can be found online at: http://www.retrovirology.com/content/8/1/85


Received:20 October 2011
Accepted:25 October 2011
Published:25 October 2011

© 2011 Hauser et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Correction

A confocal image in Figure 3B of Hauser et al. 2010 [1], showing TGN staining of Vphu-HcRed expressing cells (middle row,) was incorrect. This image has now been replaced with the correct image.

Additional file 1. Updated versions of Figure 3 of Hauser et al. 2010 [1]. Redistribution of tetherin to an intracellular compartment by HIV anti-tetherin factors. (A) The percentage of HeLa cells displaying tetherin concentrated in a perinuclear compartment (PNC) was calculated for 100 cells, from either control (Ctrl.) cells or cells transfected with 2 μg of Vpu or ROD10 Env expression plasmids. Mean +/- SEM is shown for n = 2 independent experiments. (B) HeLa cells transfected with either Vpu (Vphu-HcRed) or ROD10 Env, showed increased concentration of tetherin in a perinuclear compartment (arrowed), that co-stained with the TGN marker, TGN46. The triple color merged image is shown. Scale bars represent 10 μM.

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References

  1. Hauser Heiko, Lopez LisaA, Yang SuJ, Oldenburg JillE, Exline ColinM, Guatelli JohnC, Cannon PaulaM: HIV-1 Vpu and HIV-2 Env counteract BST-2/tetherin by sequestration in a perinuclear compartment.

    Retrovirology 2010, 7:51. PubMed Abstract | BioMed Central Full Text | PubMed Central Full Text OpenURL