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This article is part of the supplement: 15th International Conference on Human Retroviruses: HTLV and Related Viruses

Open Access Meeting abstract

Association between Human T-Cell Lymphotropic Virus Type 1 and 2 (HTLV 1/2) infection and tuberculosis: systematic review and meta-analysis

Sérgio Arruda12*, Camila Loureiro1, Marcos Almeida1, Dayana Mendes2, Maria F R Grassi12, José R Lapa3, Afrânio Kritski3, Kristien Verdonck45, Eduardo Gotuzzo4 and Bernardo Galvão-Castro12*

Author Affiliations

1 Escola Bahiana de Medicina e Saúde Pública, Salvador, Bahia, Brazil

2 Laboratório Avançado de Saúde Pública, Centro de Pesquisas Gonçalo Moniz, Fiocruz, Salvador, Bahia, Brazil

3 Universidade Federal do Rio de Janeiro,Faculdade de Medicina, RJ, Brazil

4 Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru

5 Institute of Tropical Medicine, Antwerp, Belgium

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Retrovirology 2011, 8(Suppl 1):A80  doi:10.1186/1742-4690-8-S1-A80

The electronic version of this article is the complete one and can be found online at: http://www.retrovirology.com/content/8/S1/A80


Published:6 June 2011

© 2011 Arruda et al; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Background

HTLV-1 infection alters the immune function and increases the risk of several infectious diseases. In this meta-analysis, we assess the association between HTLV- 1/2 and active tuberculosis (TB).

Methods

Four databases were searched for relevant articles that describe the frequency of HTLV- 1/2 infection among TB patients and control groups of healthy individuals or patients without a history of TB. Data were analyzed using the EasyMA software.

Results

The search yielded two hundred and eight articles. Six met the inclusion criteria and were included in the meta-analysis. The estimated relative risk of HTLV- 1/2 infection in TB patients was 3.25 times higher than in the population based control groups.

Conclusion

Patients with active TB have a higher risk of HTLV- 1/2 infection. Prospective studies involving latent tuberculosis infection (LTBI) in HTLV-1-infected individuals are necessary to evaluate the potential benefit of TB chemoprophylaxis.