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SAMHD1: a new contributor to HIV-1 restriction in resting CD4+ T-cells

Li Wu

Author Affiliations

Center for Retrovirus Research, Department of Veterinary Bioscience, Department of Microbial Infection and Immunity, The Ohio State University, 1900 Coffey Road, Columbus, OH, 43210, USA

Retrovirology 2012, 9:88  doi:10.1186/1742-4690-9-88

Published: 23 October 2012


Resting CD4+ T-cells are critical for establishing HIV-1 reservoirs. It has been known for over two decades that resting CD4+ T-cells are refractory to HIV-1 infection, but the underlying mechanisms are not fully understood. Compared with activated CD4+ T-cells that support HIV-1 infection, resting CD4+ T-cells have lower levels of dNTPs, which limit HIV-1 reverse transcription. The dNTPase SAMHD1 has been identified as an HIV-1 restriction factor in non-cycling myeloid cells. Two recent studies revealed that SAMHD1 restricts HIV-1 infection in resting CD4+ T-cells, suggesting a common mechanism of HIV-1 restriction in non-cycling cells that may contribute to viral immunopathogenesis.