Identification of a novel resistance (E40F) and compensatory (K43E) substitution in HIV-1 reverse transcriptase.

Huigen MC, van Ham PM, de Graaf L, Kagan RM, Boucher CA, Nijhuis M.

Retrovirology. 2008 Feb 13;5:20.

PMID: 18271957 [PubMed - indexed for MEDLINE]

Related Articles Free article in PMC

N348I in the connection domain of HIV-1 reverse transcriptase confers zidovudine and nevirapine resistance.

Yap SH, Sheen CW, Fahey J, Zanin M, Tyssen D, Lima VD, Wynhoven B, Kuiper M, Sluis-Cremer N, Harrigan PR, Tachedjian G.

PLoS Med. 2007 Dec;4(12):e335.

PMID: 18052601 [PubMed - indexed for MEDLINE]

Related Articles Free article in PMC

NNRTI-selected mutations at codon 190 of human immunodeficiency virus type 1 reverse transcriptase decrease susceptibility to stavudine and zidovudine.

Paolucci S, Baldanti F, Campanini G, Cancio R, Belfiore A, Maga G, Gerna G.

Antiviral Res. 2007 Nov;76(2):99-103. Epub 2007 Jul 2.

PMID: 17640745 [PubMed - indexed for MEDLINE]

Related Articles

Fitness comparison of thymidine analog resistance pathways in human immunodeficiency virus type 1.

Hu Z, Giguel F, Hatano H, Reid P, Lu J, Kuritzkes DR.

J Virol. 2006 Jul;80(14):7020-7.

PMID: 16809307 [PubMed - indexed for MEDLINE]

Related Articles Free article in PMC

Selection of mutations in the connection and RNase H domains of human immunodeficiency virus type 1 reverse transcriptase that increase resistance to 3'-azido-3'-dideoxythymidine.

Brehm JH, Koontz D, Meteer JD, Pathak V, Sluis-Cremer N, Mellors JW.

J Virol. 2007 Aug;81(15):7852-9. Epub 2007 May 16.

PMID: 17507476 [PubMed - indexed for MEDLINE]

Related Articles Free article in PMC

Impact of human immunodeficiency virus type 1 reverse transcriptase inhibitor drug resistance mutation interactions on phenotypic susceptibility.

Trivedi V, Von Lindern J, Montes-Walters M, Rojo DR, Shell EJ, Parkin N, O'Brien WA, Ferguson MR.

AIDS Res Hum Retroviruses. 2008 Oct;24(10):1291-300.

PMID: 18844463 [PubMed - indexed for MEDLINE]

Related Articles

Molecular mechanism by which the K70E mutation in human immunodeficiency virus type 1 reverse transcriptase confers resistance to nucleoside reverse transcriptase inhibitors.

Sluis-Cremer N, Sheen CW, Zelina S, Torres PS, Parikh UM, Mellors JW.

Antimicrob Agents Chemother. 2007 Jan;51(1):48-53. Epub 2006 Nov 6.

PMID: 17088490 [PubMed - indexed for MEDLINE]

Related Articles Free article in PMC

Relative replication fitness of multi-nucleoside analogue-resistant HIV-1 strains bearing a dipeptide insertion in the fingers subdomain of the reverse transcriptase and mutations at codons 67 and 215.

Prado JG, Franco S, Matamoros T, Ruiz L, Clotet B, Menéndez-Arias L, Martínez MA, Martinez-Picado J.

Virology. 2004 Aug 15;326(1):103-12.

PMID: 15262499 [PubMed - indexed for MEDLINE]

Related Articles

Involvement of novel human immunodeficiency virus type 1 reverse transcriptase mutations in the regulation of resistance to nucleoside inhibitors.

Svicher V, Sing T, Santoro MM, Forbici F, Rodríguez-Barrios F, Bertoli A, Beerenwinkel N, Bellocchi MC, Gago F, d'Arminio Monforte A, Antinori A, Lengauer T, Ceccherini-Silberstein F, Perno CF.

J Virol. 2006 Jul;80(14):7186-98.

PMID: 16809324 [PubMed - indexed for MEDLINE]

Related Articles Free article in PMC

Mutational patterns in the HIV genome and cross-resistance following nucleoside and nucleotide analogue drug exposure.

Miller V, Larder BA.

Antivir Ther. 2001;6 Suppl 3:25-44. Review.

PMID: 11678471 [PubMed - indexed for MEDLINE]

Related Articles

Transmitted human immunodeficiency virus type 1 carrying the D67N or K219Q/E mutation evolves rapidly to zidovudine resistance in vitro and shows a high replicative fitness in the presence of zidovudine.

García-Lerma JG, MacInnes H, Bennett D, Weinstock H, Heneine W.

J Virol. 2004 Jul;78(14):7545-52.

PMID: 15220429 [PubMed - indexed for MEDLINE]

Related Articles Free article in PMC

Broad nucleoside-analogue resistance implications for human immunodeficiency virus type 1 reverse-transcriptase mutations at codons 44 and 118.

Romano L, Venturi G, Bloor S, Harrigan R, Larder BA, Major JC, Zazzi M.

J Infect Dis. 2002 Apr 1;185(7):898-904. Epub 2002 Mar 11.

PMID: 11920313 [PubMed - indexed for MEDLINE]

Related Articles

Thymidine analogue reverse transcriptase inhibitors resistance mutations profiles and association to other nucleoside reverse transcriptase inhibitors resistance mutations observed in the context of virological failure.

Marcelin AG, Delaugerre C, Wirden M, Viegas P, Simon A, Katlama C, Calvez V.

J Med Virol. 2004 Jan;72(1):162-5.

PMID: 14635026 [PubMed - indexed for MEDLINE]

Related Articles

Effect of the Q207D mutation in HIV type 1 reverse transcriptase on zidovudine susceptibility and replicative fitness.

Lu J, Whitcomb J, Kuritzkes DR.

J Acquir Immune Defic Syndr. 2005 Sep 1;40(1):20-3.

PMID: 16123676 [PubMed - indexed for MEDLINE]

Related Articles

The K65R mutation in human immunodeficiency virus type 1 reverse transcriptase exhibits bidirectional phenotypic antagonism with thymidine analog mutations.

Parikh UM, Bacheler L, Koontz D, Mellors JW.

J Virol. 2006 May;80(10):4971-7.

PMID: 16641288 [PubMed - indexed for MEDLINE]

Related Articles Free article in PMC

Effects of the Delta67 complex of mutations in human immunodeficiency virus type 1 reverse transcriptase on nucleoside analog excision.

Boyer PL, Imamichi T, Sarafianos SG, Arnold E, Hughes SH.

J Virol. 2004 Sep;78(18):9987-97.

PMID: 15331732 [PubMed - indexed for MEDLINE]

Related Articles Free article in PMC

A novel genetic pathway of human immunodeficiency virus type 1 resistance to stavudine mediated by the K65R mutation.

García-Lerma JG, MacInnes H, Bennett D, Reid P, Nidtha S, Weinstock H, Kaplan JE, Heneine W.

J Virol. 2003 May;77(10):5685-93.

PMID: 12719561 [PubMed - indexed for MEDLINE]

Related Articles Free article in PMC

Switch to unusual amino acids at codon 215 of the human immunodeficiency virus type 1 reverse transcriptase gene in seroconvertors infected with zidovudine-resistant variants.

Yerly S, Rakik A, De Loes SK, Hirschel B, Descamps D, Brun-Vézinet F, Perrin L.

J Virol. 1998 May;72(5):3520-3.

PMID: 9557630 [PubMed - indexed for MEDLINE]

Related Articles Free article in PMC

Nucleoside analog resistance caused by insertions in the fingers of human immunodeficiency virus type 1 reverse transcriptase involves ATP-mediated excision.

Boyer PL, Sarafianos SG, Arnold E, Hughes SH.

J Virol. 2002 Sep;76(18):9143-51.

PMID: 12186898 [PubMed - indexed for MEDLINE]

Related Articles Free article in PMC

Increased drug susceptibility of HIV-1 reverse transcriptase mutants containing M184V and zidovudine-associated mutations: analysis of enzyme processivity, chain-terminator removal and viral replication.

Naeger LK, Margot NA, Miller MD.

Antivir Ther. 2001 Jun;6(2):115-26.

PMID: 11491416 [PubMed - indexed for MEDLINE]

Related Articles