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Both TRIM5alpha and TRIMCyp have only weak antiviral activity in canine D17 cells.
Bérubé J, Bouchard A, Berthoux L
Retrovirology 2007, 4:68
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TRIM5 and TRIMCyp form apparent hexamers and their multimeric state is not affected by exposure to restriction-sensitive viruses or by treatment with pharmacological inhibitors
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