Volume 11 Supplement 1

16th International Conference on Human Retroviruses: HTLV and Related Viruses

Meeting abstracts

Edited by Benoit Barbeau

Publication of this supplement was funded by the Canadian Institutes of Health Research (#201206). The Supplement Editor declares that he has no competing interests.

16th International Conference on Human Retroviruses: HTLV and Related Viruses. Go to conference site.

Montreal, Canada26-30 June 2013

Page 1 of 5

16th International Conference on Human Retrovirology: HTLV and Related Retroviruses

Authors: Benoit Barbeau

Citation: Retrovirology 2014 11(Suppl 1):I1

Content type: Introduction Published on: 7 January 2014
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Clinical features and outcome of adult T-cell leukemia/lymphoma: University of Miami experience

Authors: Agustin Pimentel, Isildhina Reis, Jennifer R Chapman-Fredricks and Juan Carlos Ramos

Citation: Retrovirology 2014 11(Suppl 1):O1

Content type: Oral presentation Published on: 7 January 2014
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The phase-I study of a therapeutic vaccine to ATL patients with autologous dendritic cells pulsed with peptides corresponding to Tax-specific CTL epitopes

Authors: Youko Suehiro, Atsuhiko Hasegawa, Tadafumi Iino, Amane Sasada, Nobukazu Watanabe, Ilseung Choi, Tetsuya Fukuda, Shigeo Takaishi, Ryuji Tanosaki, Atae Utsunomiya, Osamu Miura, Masao Matsuoka, Takanori Teshima, Koichi Akashi, Jun Okamura, Mari Kannagi…

Citation: Retrovirology 2014 11(Suppl 1):O2

Content type: Oral presentation Published on: 7 January 2014
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Mogamulizumab, an anti-CCR4 monoclonal antibody, is a potent therapeutic option for adult T-cell leukemia-lymphoma

Authors: Atae Utsunomiya

Citation: Retrovirology 2014 11(Suppl 1):O3

Content type: Oral presentation Published on: 7 January 2014
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The combination of arsenic, interferon-alpha, and zidovudine restores an “immunocompetent-like” micro-environment in patients with adult T-cell leukemia lymphoma

Authors: Ghada Kchour, SA Rahim Rezaee, Reza Farid, Akram Ghantous, Houshang Rafatpana, Mahdi Tarhini, Mohamad-Mehdi Kooshyar, Hiba El Hajj, Fadwa Berry, Roudaina Nasser, Abbas Shirdel, Zeina Dassouki, Mohamad Ezzedine, Hossein Rahimi, Ardeshir Ghavamzadeh, Hugues de Thé…

Citation: Retrovirology 2014 11(Suppl 1):O4

Content type: Oral presentation Published on: 7 January 2014
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Haematological and molecular responses in patients with chronic ATLL treated with zidovudine and interferon-α

Authors: Andrew Hodson, Maria-Antonietta Demontis, Lucy Cook, Nicolas Gillet, Anat Melamed, Charles RM Bangham and Graham P Taylor

Citation: Retrovirology 2014 11(Suppl 1):O5

Content type: Oral presentation Published on: 7 January 2014
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Clinical trial of a humanized monoclonal anti-IL15Rβ (CD122), in HTLV-1 associated myelopathy/ tropical spastic paraparesis (HAM/TSP)

Authors: Raya Massoud, Yoshimi Enose-Akahata, Giovanna S Brunetto, Joan Ohayon, Kaylan Fenton, Irene Cortese, Thomas A Waldmann and Steven Jacobson

Citation: Retrovirology 2014 11(Suppl 1):O6

Content type: Oral presentation Published on: 7 January 2014
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Clinical features of familial HAM/TSP

Authors: Satoshi Nozuma, Eiji Matsuura, Toshio Matsuzaki, Osamu Watanabe, Ryuji Kubota, Shuji Izumo and Hiroshi Takashima

Citation: Retrovirology 2014 11(Suppl 1):O7

Content type: Oral presentation Published on: 7 January 2014
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HTLV-1 infection modulates the immune response in HIV-HCV coinfected patients and may increase spontaneous HCV clearance

Authors: Fabianna Bahia, Marcos H Abrahão, Eduardo M Netto, Patricia Bozza and Carlos Brites

Citation: Retrovirology 2014 11(Suppl 1):O8

Content type: Oral presentation Published on: 7 January 2014
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Complete prevention of HTLV-1 infection in humanized mice (hu-PBL SCID) by a neutralizing monoclonal antibody to envelope gp46

Authors: Mineki Saito, Reiko Tanaka, Akira Kodama and Yuetsu Tanaka

Citation: Retrovirology 2014 11(Suppl 1):O9

Content type: Oral presentation Published on: 7 January 2014
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A recombinant attenuated candidate vaccine that efficiently and persistently protects against bovine leukemia virus in herds

Authors: Sabrina M Rodríguez, Gerónimo Gutiérrez, Nicolas Gillet, Karina Trono and Luc Willems

Citation: Retrovirology 2014 11(Suppl 1):O10

Content type: Oral presentation Published on: 7 January 2014
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IL-15 deficient Tax mice reveal a role for IL-1α in tumor immunity

Authors: Daniel A Rauch, John C Harding and Lee Ratner

Citation: Retrovirology 2014 11(Suppl 1):O11

Content type: Oral presentation Published on: 7 January 2014
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STLV-1-infected Japanese macaque as a model of HTLV-1 infection

Authors: Michi Miura, Junko Tanabe, Kenji Sugata, Tiejun Zhao, Guangyong Ma, Paola Miyazato, Jun-ichiro Yasunaga and Masao Matsuoka

Citation: Retrovirology 2014 11(Suppl 1):O12

Content type: Oral presentation Published on: 7 January 2014
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Both orf-I isoforms, p12 and p8, are required for efficient HTLV-1 infection and persistence

Authors: Cynthia Pise-Masison, Maria Fernanda de Castro-Amarante, Cody Buchmann, Yoshimi Enoso-Akahata, Claudio Fenezia, Dustin Edwards, Luiz Carlos Junior Alcantara, Izabela Bialuk, Steven Jacobson, Bernardo Galvao-Castro, Antoine Gessain and Genoveffa Franchini

Citation: Retrovirology 2014 11(Suppl 1):O13

Content type: Oral presentation Published on: 7 January 2014
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HTLV-1 world distribution and estimation of the number of asymptomatic infected carriers

Authors: Antoine Gessain and Olivier Cassar

Citation: Retrovirology 2014 11(Suppl 1):O14

Content type: Oral presentation Published on: 7 January 2014
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Telomere length, proviral load and neurologic impairment in HTLV-1-and HTLV-2-infected humans

Authors: Benjamin Usadi, Roberta Bruhn, Jue Lin, Tzong-Hae Lee, Elizabeth Blackburn and Edward L Murphy

Citation: Retrovirology 2014 11(Suppl 1):O15

Content type: Oral presentation Published on: 7 January 2014
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Comparison of human T cell leukemia virus-1/2 (HTLV-1/2) screening assays in South America: Implications in the loss of blood units

Authors: Gabriela Pataccini, Camila Cánepa, Jimena Salido, Cecilia M Delfino, Jorgelina Blejer, Roberto Fernández, Eulalia Rodríguez, Adriana Alter, Williams Pedrozo, Richard Malan, Elida Iriarte, Gustavo Duarte, Vanessa Schneider, Sergio Bontti, Cristina Salomón, Marcelo Borda…

Citation: Retrovirology 2014 11(Suppl 1):O16

Content type: Oral presentation Published on: 7 January 2014
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Impact of urinary incontinence on the quality of life (QoL) of women living with HTLV-1 in Salvador, Brazil

Authors: Carolina CC de Campos, Ana Karina Galvão-Barroso, Hugo Novais, Marcelo Carvalho, Breno L Araújo, Ney Boa-Sorte, Maria Fernanda Grassi, Ubirajara Barroso Jr and Bernardo Galvão-Castro

Citation: Retrovirology 2014 11(Suppl 1):O17

Content type: Oral presentation Published on: 7 January 2014
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IL28B gene polymorphism SNP rs8099917 allele GG is associated with HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in HTLV-1 carriers

Authors: Tatiane Assone dos Santos, Fernando Vieira de Souza, Karen Oliveira Gaester, Daniela Cardeal da Silva, Luiz Augusto Marcondes Fonseca, Olinda do Carmo Luiz, João Renato Rebello Pinho, Alberto JS Duarte, Augusto Penalva de Oliveira and Jorge Casseb

Citation: Retrovirology 2014 11(Suppl 1):O18

Content type: Oral presentation Published on: 7 January 2014
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Host restriction factor SAMHD1 limits human T-cell leukemia virus (HTLV-1) infection of primary monocytes via the innate immune sensor STING

Authors: Alexandre Sze, S Mehdi Belgnaoui, Rongtuan Lin, Julien van Grevenynghe and John Hiscott

Citation: Retrovirology 2014 11(Suppl 1):O19

Content type: Oral presentation Published on: 7 January 2014
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Distinct DC subsets are not equally susceptible to HTLV-1 infection

Authors: Sandrine Alais, Audrey Glaize, Anne Cachat, Florian Lamouche, Renaud Mahieux and Hélène Dutartre

Citation: Retrovirology 2014 11(Suppl 1):O20

Content type: Oral presentation Published on: 7 January 2014
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HTLV-1 gene expression by individual infected clones determines susceptibility to lysis by cytotoxic T lymphocytes specific for Tax and HBZ

Authors: Aileen G Rowan, Amy McCallin, Heather A Niederer, Silva Hilburn, Lucy Cook, Graham P Taylor and Charles RM Bangham

Citation: Retrovirology 2014 11(Suppl 1):O21

Content type: Oral presentation Published on: 7 January 2014
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Superior antiviral and antiproliferative activity of IFN-beta vs. IFN-alpha in primary ATL cells occurs downstream of STAT1 signaling

Authors: Ricardo Khouri, Gilvaneia Silva-Santos, Lourdes Farre, Achilea Bittencourt, Anne-Mieke Vandamme and Johan Van Weyenbergh

Citation: Retrovirology 2014 11(Suppl 1):O22

Content type: Oral presentation Published on: 7 January 2014
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Humoral immune response to HTLV-1 basic leucine zipper factor (HBZ) in HTLV-1-infected individuals

Authors: Yoshimi Enose-Akahata, Anna Abrams, Raya Massoud, Izabela Bialuk, Kory R Johnson, Patrick L Green, Elizabeth M Maloney and Steven Jacobson

Citation: Retrovirology 2014 11(Suppl 1):O23

Content type: Oral presentation Published on: 7 January 2014
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IFN-α suppresses HTLV-1 expression via PKR in infected cells and renders them susceptible to AZT through p53 activation in AZT/IFN-α treatment

Authors: Shuichi Kinpara, Mami Kijiyama, Ayako Takamori, Atsuhiko Hasegawa, Amane Sasada, Takao Masuda, Yuetsu Tanaka, Atae Utsunomiya and Mari Kannagi

Citation: Retrovirology 2014 11(Suppl 1):O24

Content type: Oral presentation Published on: 7 January 2014
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Virus-induced CXCL10-CXCR3 positive feedback loop via astrocytes is critical for maintaining chronic inflammatory lesions in HAM/TSP

Authors: Tomoo Sato, Hitoshi Ando, Utano Tomaru, Mari Yoshida, Atae Utsunomiya, Junji Yamauchi, Natsumi Araya, Naoko Yagishita, Ariella Coler-Reilly, Steven Jacobson and Yoshihisa Yamano

Citation: Retrovirology 2014 11(Suppl 1):O25

Content type: Oral presentation Published on: 7 January 2014
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HAM/TSP introduction: systematic review of HAM/TSP clinical trials

Authors: Rebecca Anderson and Fabiola Martin

Citation: Retrovirology 2014 11(Suppl 1):O26

Content type: Oral presentation Published on: 7 January 2014
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Will our dreams ever come true: treatment options for patients with HAM/TSP in 10 years

Authors: Cynthia Pise-Masison

Citation: Retrovirology 2014 11(Suppl 1):O27

Content type: Oral presentation Published on: 7 January 2014
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Wish list: which biomarker studies in HAM/TSP should be funded by the God of all trial funds?

Authors: Yoshihisa Yamano

Citation: Retrovirology 2014 11(Suppl 1):O28

Content type: Oral presentation Published on: 7 January 2014
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Through the looking glass: CNS imaging findings in HAM/TSP

Authors: Raya Massoud

Citation: Retrovirology 2014 11(Suppl 1):O29

Content type: Oral presentation Published on: 7 January 2014
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ATLL introduction: is there a standard of care for treatment of adult T cell Leukemia Lymphoma?

Authors: Ali Bazarbachi, Felipe Suarez, Ambroise Marcais and Olivier Hermine

Citation: Retrovirology 2014 11(Suppl 1):O30

Content type: Oral presentation Published on: 7 January 2014
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Biomarkers and clonality before and after treatment

Authors: Juan Carlos Ramos

Citation: Retrovirology 2014 11(Suppl 1):O31

Content type: Oral presentation Published on: 7 January 2014
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Allogeneic BMT in ATL: whom to transplant and which modality to use

Authors: Mari Kannagi

Citation: Retrovirology 2014 11(Suppl 1):O32

Content type: Oral presentation Published on: 7 January 2014
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Can we cure ATL: new drugs and targeting ATL stem cells

Authors: Olivier Hermine

Citation: Retrovirology 2014 11(Suppl 1):O33

Content type: Oral presentation Published on: 7 January 2014
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HTLV-1 epigenetic modification of the FoxP3 TSDR in HAM/TSP decreases the functional proliferative suppression of Tregs

Authors: Monique R Anderson, Yoshimi Akahata, Raya Massoud, Nyater Ngouth, Unsong Oh and Steven Jacobson

Citation: Retrovirology 2014 11(Suppl 1):O34

Content type: Oral presentation Published on: 7 January 2014
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Augmentation of donor-derived Tax-specific CTL responses by a novel Tax epitope-specific CD4+ helper T-cells in ATL patients after allogeneic hematopoietic stem cell transplantation

Authors: Atsuhiko Hasegawa, Yotaro Tamai, Ayako Takamori, Amane Sasada, Ryuji Tanosaki, Ilseung Choi, Atae Utsunomiya, Yasuhiro Maeda, Yoshihisa Yamano, Tetsuya Eto, Ki-Ryang Koh, Hirohisa Nakamae, Youko Suehiro, Koji Kato, Shigeki Takemoto, Jun Okamura…

Citation: Retrovirology 2014 11(Suppl 1):O35

Content type: Oral presentation Published on: 7 January 2014
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Lack of recall response to Tax in ATL and HAM/TSP patients but not in asymptomatic carriers of human T-cell leukemia virus type 1

Authors: Sharrón L Manuel, Mohit Sehgal, John Connolly, George Makedonas, Zafar K Khan, Jay Gardner, James J Goedert, Michael R Betts and Pooja Jain

Citation: Retrovirology 2014 11(Suppl 1):O36

Content type: Oral presentation Published on: 7 January 2014
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Cytokines, chemokines and leukotrienes profile and signature analysis in HTLV-1 infection as an evidence of disease progression

Authors: Ana LB Starling, Denise U Gonçalves, Vanessa Peruhype-Magalhães, Jordana Coelho-dos-Reis, José R Lambertucci, Ludimila Labanca, Silvio R Souza Pereira, Marina L Martins, João G Ribas, Andréa Teixeira-Carvalho, Bruno C Trindade, Lucia H Faccioli, Anna BF Carneiro-Proietti and Olindo A Martins-Filho

Citation: Retrovirology 2014 11(Suppl 1):O37

Content type: Oral presentation Published on: 7 January 2014
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Correlation of increased CXCL13 with intrathecal humoral immune responses to HTLV-1 in CSF of patients with HAM/TSP

Authors: Yoshimi Enose-Akahata, Raya Massoud, Jussi O Virtanen and Steven Jacobson

Citation: Retrovirology 2014 11(Suppl 1):O38

Content type: Oral presentation Published on: 7 January 2014
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Neutralizing antibodies against human T cell leukemia virus type-I (HTLV-1) eradicate HTLV-1 in combination with autologous peripheral blood mononuclear cells via antibody-dependent cellular cytotoxicity while preventing new infection

Authors: Yuetsu Tanaka, Yoshiaki Takahashi, Akira Kodama, Reiko Tanaka and Mineki Saito

Citation: Retrovirology 2014 11(Suppl 1):O39

Content type: Oral presentation Published on: 7 January 2014
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Anti-CD3 monoclonal antibody as a possible therapeutic alternative in HAM/TSP

Authors: Johan Van Weyenbergh, Daniele Decanine, Saul Velloso Schnitman, Ana Maria Moro, Jorge Kalil, Ramon A Kruschewsky and Bernardo Galvão-Castro

Citation: Retrovirology 2014 11(Suppl 1):O40

Content type: Oral presentation Published on: 7 January 2014
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Post-translational modifications of HTLV-1 Tax carboxy-terminal domain: role in cellular transformation

Authors: Julie Lodewick, Anne Sophie Rinaldi and Françoise Bex

Citation: Retrovirology 2014 11(Suppl 1):O41

Content type: Oral presentation Published on: 7 January 2014
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Low levels of HTLV-2 Tax conjugation to ubiquitin and SUMO do not impede Tax-mediated activation of NF-κB

Authors: Chloé Journo, Amandine Bonnet, Arnaud Favre-Bonvin, Jocelyn Turpin, Jennifer Vinera, Emilie Côté, Sébastien A Chevalier, Youmna Kfoury, Ali Bazarbachi, Claudine Pique and Renaud Mahieux

Citation: Retrovirology 2014 11(Suppl 1):O42

Content type: Oral presentation Published on: 7 January 2014
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The HTLV-1 encoded bZIP factor promotes cell proliferation and genetic instability through activation of oncogenic microRNAs

Authors: Céline Vernin, Christiane Pinatel, Antoine Gessain, Olivier Gout, Marie-Hélène Delfau-Larue, Nicolas Nazaret, Catherine Legras-Lachuer, Eric Wattel and Franck Mortreux

Citation: Retrovirology 2014 11(Suppl 1):O43

Content type: Oral presentation Published on: 7 January 2014
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Activation of CDK4 by Tax chemosensitizes p53-mutant cells to DNA damage

Authors: O John Semmes, Xin Guo, Valia T Mihaylova and Gary M Kupfer

Citation: Retrovirology 2014 11(Suppl 1):O44

Content type: Oral presentation Published on: 7 January 2014
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Human T-cell leukemia virus type 1 (HTLV-1) Tax oncoprotein induces DNA damages through Activation-Induced cytidine Deaminase (AID)

Authors: Aurélien Riquet, Sébastien Chevalier, Julien Villaudy, Louis Gazzolo, Jean-Pierre Vartanian, Renaud Mahieux, Madeleine Duc-Dodon and Nathalie Bonnefoy

Citation: Retrovirology 2014 11(Suppl 1):O45

Content type: Oral presentation Published on: 7 January 2014
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Exosomes derived from HTLV-1 infected cells contain the viral protein Tax

Authors: Aarthi Narayanan, Elizabeth Jaworski, Rachel Van Duyne, Sergey Iordanskiy, Irene Guendel, Ravi Das, Robert Currer, Gavin Sampey, Myung Chung, Kylene Kehn-Hall, Charles Bailey, Anastas Popratiloff and Fatah Kashanchi

Citation: Retrovirology 2014 11(Suppl 1):O46

Content type: Oral presentation Published on: 7 January 2014
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Control of LTR transcription by SWI/SNF BAF and PBAF complexes

Authors: Irene Guendel, Rachel Van Duyne and Fatah Kashanchi

Citation: Retrovirology 2014 11(Suppl 1):O47

Content type: Oral presentation Published on: 7 January 2014
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Upregulation of the transcription elongation factor ELL2 by Tax as a novel mechanism of HTLV-1 gene expression

Authors: Melanie C Mann, Sarah Strobel, Bernhard Fleckenstein and Andrea K Kress

Citation: Retrovirology 2014 11(Suppl 1):O48

Content type: Oral presentation Published on: 7 January 2014
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Double-stranded RNA adenosine deaminase ADAR1 enhances both T cell susceptibility to human T-cell leukemia virus type 1 and 2 and viral replication

Authors: Anne Cachat, Sébastien A Chevalier, Sandrine Alais, Adrien Boniface, Nga Ling Ko, Antoine Gessain, Hélène Dutartre and Renaud Mahieux

Citation: Retrovirology 2014 11(Suppl 1):O49

Content type: Oral presentation Published on: 7 January 2014
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16th International Conference on Human Retroviruses: HTLV and Related Viruses

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