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Research
Retrovirology 2012, 9:42 (14 May 2012)T cell independent secondary antibody responses to the envelope protein of simian immunodeficiency virus
Membrane-bound trimeric Env seems to be responsible for the maintenance of high levels of anti-Env antibodies during progression to AIDS. This T cell independent secondary antibody response may prevent T cell-dependent affinity maturation and thus contribute to viral immune escape by favoring persistence of non-protective antibodies. -
Research
Retrovirology 2012, 9:41 (10 May 2012)The prototype foamy virus protease is active independently of the integrase domain
This paper shows that the FV integrase is required for Pol encapsidation and that the FV PR activity is integrase independent. The study shows that an active PR can be encapsidated in trans as a GagPR-RT fusion protein. -
Research
Retrovirology 2012, 9:40 (9 May 2012)Limited SHIV env diversification in macaques failing oral antiretroviral pre-exposure prophylaxis
Infection during pre-exposure prophylaxis (PrEP) limits early virus evolution likely because of a direct antiviral effect of PrEP and/or reduced target cell availability. Reduced virus diversification during early infection might enhance immune control by slowing the selection of escape mutants -
This review highlights the role of HLA-C in association with HIV-1 viral load, but also addresses the contradiction of the association between high cell surface expression of an inhibitory molecule and strong cell-mediated immunity. To explore additional mechanisms of control of HIV-1 replication by HLA-C, this review addresses specific features of the molecule, like its tendency to be expressed as open conformer upon cell activation, which endows it with a unique capacity to associate with other cell surface molecules as well as with HIV-1 proteins. -
Research
Retrovirology 2012, 9:38 (8 May 2012)HIV-1-encoded antisense RNA suppresses viral replication for a prolonged period
The present study identified an accurate structure of the major form of antisense RNAs expressed from the HIV-1NL4-3 provirus and demonstrated a new role of the antisense RNA in viral replication, suggesting a novel viral mechanism that regulates self-limited replication of HIV-1. -
Research
Retrovirology 2012, 9:37 (3 May 2012)Protein kinase C-delta regulates HIV-1 replication at an early post-entry step in macrophages
This study identified PKC-delta as a major cellular cofactor for HIV-1 replication in macrophages. PKC-delta was stimulated following the interaction between the virus and its target cell. Inhibition of PKC-delta blocked the replication of R5-tropic viruses in primary human macrophages. -
Research
Retrovirology 2012, 9:36 (2 May 2012)MiniCD4 protein resistance mutations affect binding to the HIV-1 gp120 CD4 binding site and decrease entry efficiency
The present study reports on the resistance induction of two subtype B HIV-1 against the most active miniCD4, M48U1, and its ancestor, M48, and how these mutated positions affect CD4bs recognition, entry efficiency, and sensitivity to other CD4bs inhibitors. Resistance against M48U1 was always associated with S375R/N substitution in both BaL and SF162; M48 resistance was associated with D474N substitution in SF162 and with H105Y substitution in BaL. - View more articles
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- HIV/AIDS Information provided by AEGIS.org
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