Retrovirology

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Kuan-Teh Jeang, United States

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Translation of MMTV Gag requires nuclear events involving splicing motifs in addition to the viral Rem protein and RmRE

This paper shows that the translation of MMTV Gag mRNA is negatively regulated by a nuclear "experience" and that viral Rem protein, viral RmRE sequence,and a splice donor and acceptor are needed to counter the negative translational effect on Gag mRNA in the cytoplasm.

Retrovirology 2012, 9:8
Relationships of PBMC microRNA expression, plasma viral load, and CD4+ T-cell count in HIV-1-infected elite suppressors and viremic patients

miRNA profiles, obtained using multiple acquisition, data processing, and analysis methods, distinguished ES and uninfected controls from viremic HIV-1-infected patients. For several miRNAs, however, ES and viremic patients shared similar expression patterns. Differentially expressed miRNAs included those with reported roles in HIV-1 latency (miR-29 family members, miRs -125b and -150). Others, such as miR-31 and miR-31*, had no previously reported connection with HIV-1 infection but were found here to differ significantly with uncontrolled HIV-1 replication.

Retrovirology 2012, 9:5

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Comments

Incorrect interpretation of previously published data in the...

Comment on: Subramanian et al. Retrovirology 2012, 8:90
Correction of a typographical error in the abstract

Comment on: Marlin et al. Retrovirology 2011, 8:58
Email address update

Comment on: Ristic et al. Retrovirology 2011, 7:73

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Retrovirology is a stringently peer-reviewed journal edited by Kuan-Teh Jeang (USA), Monsef Benkirane (France), Ben Berkhout (the Netherlands), Masahiro Fujii (Japan), Ariberto Fassati (UK), Michael Lairmore (USA), Andrew Lever (UK), and Mark Wainberg (Canada) with the assistance of an internationally renowned Editorial Board.

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