Retrovirology

Editor-in-Chief

Kuan-Teh Jeang, United States

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Articles

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Research

Insights into the structure and activity of the prototype foamy virus RNase H

Leo B, Hartl MJ, Schweimer K, Mayr F and Wohrl BM Retrovirology 2012, 9:14 (10 February 2012)

This paper demonstrates that the independent PFV RNase H domain is structured and active. The presence of the C-helix in PFV RNase H could be confirmed by assigning the protein backbone and calculating the chemical shift index using NMR spectroscopy.
Research

Spt6 levels are modulated by PAAF1 and proteasome to regulate the HIV-1 LTR

Nakamura M, Basavarajaiah P, Rousset E, Beraud C, Latreille D, Henaoui IS, Lassot I, Mari B et al. Retrovirology 2012, 9:13 (8 February 2012)

This study shows that Spt6 is targeted by proteasome in the absence of PAAF1. PAAF1 interacts with the N-terminus of Spt6, suggesting that PAAF1 protects Spt6 from proteolysis.
Research

FIV establishes a latent infection in feline peripheral blood CD4+ T lymphocytes in vivo during the asymptomatic phase of infection

Murphy B, Vapniarsky N, Hillman C, Castillo D, McDonnel S, Moore P, Luciw PA and Sparger EE Retrovirology 2012, 9:12 (7 February 2012)

This study shows that viral LTR and gag sequences amplified from peripheral blood mononuclear cells during early and chronic stages of infection demonstrated minimal to no viral sequence variation consistent with tight transcriptional latency in FIV infection in vivo.
Research

Systemic inhibition of myeloid dendritic cells by circulating HLA class I molecules in HIV-1 infection

Huang J, Al-Mozaini M, Rogich J, Carrington MF, Seiss K, Pereyra F, Lichterfeld M and Yu XG Retrovirology 2012, 9:11 (30 January 2012)

During progressive HIV-1 infection, soluble HLA class I molecules can contribute to systemic immune dysfunction by inhibiting the antigen-presenting properties of myeloid dendritic cells through interactions with inhibitory myelomonocytic HLA class I receptors.
Research

Bone marrow stromal cell antigen 2 (BST-2) restricts mouse mammary tumor virus (MMTV) replication in vivo

Jones PH, Mehta HV, Maric M, Roller RJ and Okeoma CM Retrovirology 2012, 9:10 (27 January 2012)

The findings in this work show that BST-2 restricts MMTV release from naturally infected cells and that BST-2 is an antiviral factor in vivo.
Short report

The W100 pocket on HIV-1 gp120 penetrated by b12 is not a target for other CD4bs monoclonal antibodies

Duenas-Decamp MJ, O'Connell OJ, Corti D, Zolla-Pazner S and Clapham PR Retrovirology 2012, 9:9 (27 January 2012)

This study indicates that the b12 W100 pocket on gp120 is targeted infrequently by CD4bs mabs. This site is therefore not a priority for preservation in vaccines aiming to elicit antibodies targeting the CD4bs.
Research

Translation of MMTV Gag requires nuclear events involving splicing motifs in addition to the viral Rem protein and RmRE

Boeras I, Sakalian M and West JT Retrovirology 2012, 9:8 (25 January 2012)

This paper shows that the translation of MMTV Gag mRNA is negatively regulated by a nuclear "experience" and that viral Rem protein, viral RmRE sequence,and a splice donor and acceptor are needed to counter the negative translational effect on Gag mRNA in the cytoplasm.

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Comments

Incorrect interpretation of previously published data in the...

Comment on: Subramanian et al. Retrovirology 2012, 8:90
Correction of a typographical error in the abstract

Comment on: Marlin et al. Retrovirology 2011, 8:58
Email address update

Comment on: Ristic et al. Retrovirology 2011, 7:73

Aims & scope

Retrovirology is a stringently peer-reviewed journal edited by Kuan-Teh Jeang (USA), Monsef Benkirane (France), Ben Berkhout (the Netherlands), Masahiro Fujii (Japan), Ariberto Fassati (UK), Michael Lairmore (USA), Andrew Lever (UK), and Mark Wainberg (Canada) with the assistance of an internationally renowned Editorial Board.

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