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Volume 11 Supplement 1

16th International Conference on Human Retroviruses: HTLV and Related Viruses

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HTLV-1 infection modulates the immune response in HIV-HCV coinfected patients and may increase spontaneous HCV clearance

Retrovirology volume 11, Article number: O8 (2014) Cite this article

Background

HTLV-1 often infect HIV-HCV coinfected patients. The immunological consequences of triple infection are still unclear. Objective: to compare the plasma levels of 25 different cytokines in patients infected by HIV and HCV, according to their serological status to HTLV-1 infection.

Methods

We used the LUMINEX 100/200 analyzer to compare the plasma levels of 25 different cytokines for patients coinfected by HCV and HIV (N=15), or by HTLV-1, HCV and HIV(N=18, 3 of them spontaneously cleared HCV).

Results

We detected a significant increase in median plasma levels of 6 different cytokines (Table 1) for patients coinfected by HTLV-1.Only the 3 patients with HCV spontaneous clearance showed detectable levels of IL-15 (p=0.06). Levels of remaining 18 cytokines were similar for all groups.

Table 1
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Conclusions

Infection by HTLV-1, in HIV-HCV coinfected patients, seems to induce a greater release of pro-inflamatory cytokines. This can be associated with a higher rate of HCV spontaneous clearance.

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Authors and Affiliations

  1. Laboratório de Pesquisa em Infectologia, Complexo Hospitalar Prof. Edgard Santos – Federal University of Bahia, Brazil

    Fabianna Bahia, Marcos H Abrahão, Eduardo M Netto & Carlos Brites

  2. FIOCRUZ, Rio de Janeiro, Brazil

    Patricia Bozza

Authors
  1. Fabianna Bahia
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  2. Marcos H Abrahão
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  3. Eduardo M Netto
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  4. Patricia Bozza
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  5. Carlos Brites
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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution License ( https://creativecommons.org/licenses/by/2.0 ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver ( https://creativecommons.org/publicdomain/zero/1.0/ ) applies to the data made available in this article, unless otherwise stated.

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Bahia, F., Abrahão, M.H., Netto, E.M. et al. HTLV-1 infection modulates the immune response in HIV-HCV coinfected patients and may increase spontaneous HCV clearance. Retrovirology 11 (Suppl 1), O8 (2014). https://doi.org/10.1186/1742-4690-11-S1-O8

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  • DOI: https://doi.org/10.1186/1742-4690-11-S1-O8

Keywords

Retrovirology

ISSN: 1742-4690

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