The HTLV-1 Tax interactome

doi:10.1186/1742-4690-5-76

Retrovirology

Volume 5

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Boxus M
Twizere JC
Legros S
Dewulf JF
Kettmann R
Willems L

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Twizere JC
Legros S
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Kettmann R
Willems L
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Review

The HTLV-1 Tax interactome

Mathieu Boxus , Jean-Claude Twizere , Sébastien Legros , Jean-François Dewulf , Richard Kettmann and Luc Willems

University Academia Wallonie-Europe, Molecular and Cellular Biology at FUSAGx, Gembloux, Belgium

author email corresponding author email

Retrovirology 2008, 5:76doi:10.1186/1742-4690-5-76


Published:	14 August 2008

Abstract

The Tax1 oncoprotein encoded by Human T-lymphotropic virus type I is a major determinant of viral persistence and pathogenesis. Tax1 affects a wide variety of cellular signalling pathways leading to transcriptional activation, proliferation and ultimately transformation. To carry out these functions, Tax1 interacts with and modulates activity of a number of cellular proteins. In this review, we summarize the present knowledge of the Tax1 interactome and propose a rationale for the broad range of cellular proteins identified so far.