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Raltegravir, elvitegravir, and metoogravir: the birth of "me-too" HIV-1 integrase inhibitors

Erik Serrao, Srinivas Odde, Kavya Ramkumar and Nouri Neamati*

Author Affiliations

Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, School of Pharmacy, 1985 Zonal Avenue, Los Angeles, CA 90089, USA

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Retrovirology 2009, 6:33 doi:10.1186/1742-4690-6-33


The electronic version of this article is the complete one and can be found online at: http://www.retrovirology.com/content/6/1/33


Received:7 April 2009
Accepted:8 April 2009
Published:8 April 2009

© 2009 Serrao et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Correction to Erik Serrao, Srinivas Odde, Kavya Ramkumar and Nouri Neamati: Raltegravir, elvitegravir, and metoogravir: the birth of "me-too" HIV-1 integrase inhibitors. Retrovirology 2009, 6:25. Since the recent publication of our article (Neamati, Retrovirology 2009, 6:25), we have noticed an error which we would like to correct and we would like to apologise to the readers for this mistake.

Correction

The structure of BMS-707035 has not been publicly released. In Figure one on page 2 and a discussion on page 5 of our published paper [1], we mistakenly assigned a structure and activity data to BMS-707035. The structure and activity data that we mentioned actually belong to a different compound from the same group. The resistance pattern of BMS-707035 is "overlapping" rather than identical to raltegravir. Please see the following references [2,3] for a detailed description of their development of pyrimidine carboxamides.

References

  1. Serrao Erik, Odde Srinivas, Ramkumar Kavya, Neamati Nouri: Raltegravir, elvitegravir, and metoogravir: the birth of "me-too" HIV-1 integrase inhibitors.

    Retrovirology 2009, 6:25. PubMed Abstract | BioMed Central Full Text | PubMed Central Full Text OpenURL

  2. Dicker IB, Samanta HK, Li Z, Hong Y, Tian Y, Banville J, Remillard RR, Walker MA, Langley DR, Krystal M: Changes to the HIV long terminal repeat and to HIV integrase differentially impact HIV integrase assembly, activity, and the binding of strand transfer inhibitors.

    J Biol Chem 2007, 282(43):31186-96. PubMed Abstract | Publisher Full Text OpenURL

  3. Dicker IB, Terry B, Lin Z, Li Z, Bollini S, Samanta HK, Gali V, Walker MA, Krystal MR: Biochemical analysis of HIV-1 integrase variants resistant to strand transfer inhibitors.

    J Biol Chem 2008, 283(35):23599-609. PubMed Abstract | Publisher Full Text OpenURL