Email updates

Keep up to date with the latest news and content from Retrovirology and BioMed Central.

This article is part of the supplement: 15th International Conference on Human Retroviruses: HTLV and Related Viruses

Open Access Meeting abstract

Exacerbated signs of an immunosuppressive AIDS-like disease in macaques infected with multiple retroviruses

Jane L Mitchell1, Simon Hood1, Ghazi Auda2, Neil M Almond1 and Nicola J Rose1*

Author Affiliations

1 Division of Retrovirology, National Institute for Biological Standards and Control, South Mimms, Potters Bar, Hertford, EN6 3QG, UK

2 Division of Virology, National Institute for Biological Standards and Control, South Mimms, Potters Bar, Hertford, EN6 3QG, UK

For all author emails, please log on.

Retrovirology 2011, 8(Suppl 1):A207  doi:10.1186/1742-4690-8-S1-A207


The electronic version of this article is the complete one and can be found online at: http://www.retrovirology.com/content/8/S1/A207


Published:6 June 2011

© 2011 Mitchell et al; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Meeting abstract

In retroviral co-infection one or more of the viruses may display altered dynamics impacting on the pathology within the host. To characterise the nature of such changes we studied cynomolgus macaques naturally infected with three retroviruses. DNA was isolated from eleven tissues from macaques infected with SFV-1 (4), SRV-2/SFV-1 (4), STLV-1/SFV-1 (3), SRV-2/STLV-1/SFV-1 (6), and one uninfected macaque. Proviral load and distribution were evaluated by quantitative PCR. Immunopathology was assessed by H&E staining and immunohistochemistry, using antibodies against T-, B-lymphocytes and macrophages in the MLN and spleen.

Our data reveal that in co-infected macaques a significant increase in the SRV-2 proviral distribution and a trend towards an increase in the proviral load of SRV-2 but not STLV-I or SFV-1 occurs Pathological changes were more adverse in co-infected macaques, identified by the presence of nodular hyperplasia or, in extreme instances, follicular depletion. A greater number of B- and T-lymphocytes and macrophages were observed in co-infected macaques than in singly-infected macaques. The atypical distribution of the B- and T-cells is suggestive of altered immunopathology. Thus co-infection increases the distribution and proviral load of SRV-2 thereby creating an atypical immunopathology within the lymphoid organs which may enhance SRV-2 pathogenesis and hinder the host’s ability to control infection.