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Generation of a packaging cell line for prolonged large-scale production of high-titer HIV-1-based lentiviral vector.

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HIV-1-based defective lentiviral vectors efficiently transduce human monocytes-derived macrophages and suppress replication of wild-type HIV-1.

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Inhibition of human immunodeficiency virus type 1 in human T cells by a potent Rev response element decoy consisting of the 13-nucleotide minimal Rev-binding domain.

Lee SW, Gallardo HF, Gilboa E, Smith C.

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Development of an Rev-independent, minimal simian immunodeficiency virus-derived vector system.

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Transduction of human CD34+ hematopoietic progenitor cells by a retroviral vector expressing an RRE decoy inhibits human immunodeficiency virus type 1 replication in myelomonocytic cells produced in long-term culture.

Bahner I, Kearns K, Hao QL, Smogorzewska EM, Kohn DB.

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Lentiviral vectors for gene therapy of HIV-1 infection.

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A single administration of lentiviral vectors expressing either full-length human immunodeficiency virus 1 (HIV-1)(HXB2) Rev/Env or codon-optimized HIV-1(JR-FL) gp120 generates durable immune responses in mice.

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Potent inhibition of human immunodeficiency virus type 1 in primary T cells and alveolar macrophages by a combination anti-Rev strategy delivered in an adeno-associated virus vector.

Inouye RT, Du B, Boldt-Houle D, Ferrante A, Park IW, Hammer SM, Duan L, Groopman JE, Pomerantz RJ, Terwilliger EF.

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A third-generation lentivirus vector with a conditional packaging system.

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Inhibition of human immunodeficiency virus type 1 (HIV-1) replication by HIV-1-based lentivirus vectors expressing transdominant Rev.

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High transdominant RevM10 protein levels are required to inhibit HIV-1 replication in cell lines and primary T cells: implication for gene therapy of AIDS.

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Drug-loaded red blood cell-mediated clearance of HIV-1 macrophage reservoir by selective inhibition of STAT1 expression.

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Effect of scaffold attachment region on transgene expression in retrovirus vector-transduced primary T cells and macrophages.

Auten J, Agarwal M, Chen J, Sutton R, Plavec I.

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Expression of small hairpin RNA by lentivirus-based vector confers efficient and stable gene-suppression of HIV-1 on human cells including primary non-dividing cells.

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Sustained expression of genes delivered directly into liver and muscle by lentiviral vectors.

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